Depending on the area treated, most folds and wrinkles require one treatment. The repeat maintenance treatment is not usually required for approximately 6 months or longer. By experience these products last almost twice as long as regular collagen injections. The great thing about Restylane is that you can replenish your natural beauty whenever you feel the need. Unlike permanent implants, Restylane always leaves you a choice when the effect of the treatment has worn off. A touch-up can be performed any time you like after the previous treatment.